N-glycan processing

Across TCGA patient cohorts, RNA activity of the N-glycan processing pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PUM1_S800, ZNF503_S237, and CCSAP_S80, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-glycan processing activity versus PUM1_S800 in UCEC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PUM1_S800 →	+0.738	+0.370	<.001	<.001	3	3
OV	ZNF503_S237 →	+1.053	+0.310	<.001	<.001	3	3
OV	CCSAP_S80 →	+0.481	+0.186	.003	<.001	3	3
OV	PER1_S645 →	+1.000	+0.340	<.001	<.001	3	3
PDAC	CHGA_S398 →	+1.539	+0.302	<.001	<.001	3	3
HNSC	TRMT112_S119 →	+1.158	+0.228	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006491 vs PUM1_S800 — UCEC

Explore this scatter interactively →