N-glycan processing

Across TCGA cell cohorts, RNA activity of the N-glycan processing pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIR1, BBOF1, and KHDC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CIR1 grouped by N-glycan processing-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CIR1 →	-0.503	-0.770	.001	.003	3	3
STOMACH	BBOF1 →	+1.060	+0.737	<.001	.003	3	3
OVARY	KHDC1 →	-1.393	-0.882	.001	.002	3	3
LUNG_NSCLC_LUSC	CCDC126 →	-1.218	-1.325	.007	.005	3	3
LUNG_NSCLC_LUSC	ZNF766 →	-0.895	-1.416	.002	.001	3	3
LUNG_NSCLC_LUSC	DNAH10OS →	-0.612	-0.924	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CIR1 by N-glycan processing activity — PANCREAS

Explore this box plot interactively →