N-glycan processing

Across TCGA cell cohorts, RNA activity of the N-glycan processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FSCN1, GTF2H4, and SSRP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-glycan processing activity versus FSCN1 in BREAST (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FSCN1 →	+2.355	+0.160	.008	.001	3	5
LUNG_NSCLC_LUSC	GTF2H4 →	+0.492	+0.250	.007	.001	3	5
CNS	SSRP1 →	+0.656	+0.113	.007	.002	3	5
SKIN	TOP3A →	+0.591	+0.094	.007	.006	3	5
SKIN	RAVER1 →	+0.984	+0.151	.004	.002	3	5
BLOOD_Leukemia	FBXO8 →	-0.584	-0.130	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006491 vs FSCN1 — BREAST

Explore this scatter interactively →