Oligosaccharide-lipid intermediate biosynthetic process

pathway activity — cross-omics
GO:0006490Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Oligosaccharide-lipid intermediate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNFAIP8, WDFY4, and DOCK11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCATNFAIP8 →-0.402-0.021<.001<.00136
CCRCCWDFY4 →-0.338-0.028.002<.00136
BRCADOCK11 →-0.254-0.021.005.00336
LSCCTNFAIP3_S645 →-0.513-0.031<.001.00335
BRCACKAP4_S26 →-0.955-0.025<.001<.00135
LSCCPHF3 →+0.177+0.028.006.00235
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration