Protein N-linked glycosylation

Across TCGA patient cohorts, RNA activity of the Protein N-linked glycosylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKBP11, EPB41L4A-AS1, and MIAT, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein N-linked glycosylation activity versus FKBP11 in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FKBP11 →	+0.548	+0.349	<.001	<.001	2	6
OV	EPB41L4A-AS1 →	-0.719	-0.164	.001	.007	3	5
OV	MIAT →	+0.582	+0.177	.005	<.001	3	5
GBM	RANBP10 →	-0.267	-0.171	.004	.002	3	5
CCRCC	GATM →	-1.305	-0.307	<.001	<.001	3	5
LSCC	CCDC85C →	-0.475	-0.186	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006487 vs FKBP11 — BRCA

Explore this scatter interactively →