Protein N-linked glycosylation

Across TCGA cell cohorts, RNA activity of the Protein N-linked glycosylation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRF1, COPS9, and ATP13A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NRF1 grouped by Protein N-linked glycosylation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NRF1 →	-0.559	-1.204	<.001	.001	3	4
LIVER	COPS9 →	-0.814	-1.608	.002	.006	3	4
BLOOD_Lymphoma	ATP13A3 →	-1.326	-1.815	.006	<.001	3	4
OVARY	GNAI2 →	-1.030	-1.043	.001	.003	3	4
OVARY	CXCL16 →	+1.873	+0.914	.001	<.001	3	4
BREAST	NCAPD3 →	-1.152	-0.879	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NRF1 by Protein N-linked glycosylation activity — PANCREAS

Explore this box plot interactively →