Protein N-linked glycosylation

Across TCGA cell cohorts, RNA activity of the Protein N-linked glycosylation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRSS2, PICALM, and SLC46A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRSS2 grouped by Protein N-linked glycosylation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRSS2 →	+0.272	+0.072	.001	.004	2	6
BONE	PICALM →	-0.288	-0.085	<.001	.001	3	4
LUNG_SCLC	SLC46A1 →	+0.325	+0.094	.006	.006	3	4
BLOOD_Lymphoma	POLN →	-0.327	-0.140	.008	.001	3	4
LARGE_INTESTINE	C1QL1 →	+0.080	+0.050	.005	.002	3	4
BLOOD_Myeloma	ETV5 →	+0.167	+0.043	.005	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRSS2 by Protein N-linked glycosylation activity — LUNG_SCLC

Explore this box plot interactively →