Protein sulfation

Across TCGA patient cohorts, RNA activity of the Protein sulfation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBA2, CD44, and XRN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein sulfation activity versus UBA2 in COAD (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UBA2 →	-0.308	-0.077	<.001	<.001	3	5
GBM	CD44 →	+0.454	+0.097	.001	<.001	3	5
GBM	XRN2 →	-0.257	-0.086	.004	.004	3	5
LUAD	LIG3 →	-0.325	-0.097	<.001	<.001	3	5
GBM	MYOF →	+0.446	+0.075	.001	.005	3	5
COAD	SAE1 →	-0.317	-0.070	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006477 vs UBA2 — COAD

Explore this scatter interactively →