Protein sulfation

Across TCGA cell cohorts, RNA activity of the Protein sulfation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPST2, TPST1, and ITGA5, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein sulfation activity versus TPST2 in LIVER (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TPST2 →	+2.662	+0.481	<.001	<.001	3	20
BONE	TPST1 →	+2.380	+1.090	<.001	.001	3	16
BREAST	ITGA5 →	+2.809	+1.046	.001	<.001	3	11
STOMACH	P3H1 →	+1.848	+1.005	.001	.001	3	10
BREAST	ASPHD2 →	+0.957	+0.944	<.001	.004	3	10
STOMACH	IKBIP →	+1.374	+0.624	<.001	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006477 vs TPST2 — LIVER

Explore this scatter interactively →