Protein deacetylation

Across TCGA patient cohorts, RNA activity of the Protein deacetylation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL10, and SORBS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deacetylation activity versus RPL5 in GBM (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.251	-0.056	<.001	<.001	3	8
BRCA	RPL10 →	-0.229	-0.025	<.001	<.001	3	7
BRCA	SORBS1 →	+0.635	+0.027	<.001	<.001	3	7
BRCA	APBB2 →	+0.307	+0.027	<.001	<.001	3	7
BRCA	LTBP4 →	+0.390	+0.020	<.001	.001	3	7
CCRCC	RPL18A →	-0.276	-0.031	.008	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006476 vs RPL5 — GBM

Explore this scatter interactively →