Protein deacetylation

Across TCGA patient cohorts, RNA activity of the Protein deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRA2B, OMD, and AGTR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deacetylation activity versus TRA2B in UCEC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRA2B →	+0.285	+0.237	.005	.006	3	6
GBM	OMD →	+0.719	+0.154	<.001	.009	3	4
COAD	AGTR1 →	+0.419	+0.638	.003	.001	3	4
COAD	AKT3 →	+0.431	+0.628	.005	.001	3	4
COAD	CNN1 →	+1.308	+0.887	<.001	<.001	3	4
CCRCC	PLN →	+1.333	+0.692	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006476 vs TRA2B — UCEC

Explore this scatter interactively →