Protein deacetylation

Across TCGA cell cohorts, RNA activity of the Protein deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR90, SETD6, and TAF1C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR90 grouped by Protein deacetylation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	WDR90 →	+1.539	+1.697	.005	<.001	2	6
CNS	SETD6 →	+0.761	+1.354	<.001	<.001	3	4
LARGE_INTESTINE	TAF1C →	+0.458	+0.787	.009	<.001	3	4
PANCREAS	ABCF3 →	+0.611	+1.224	.002	.002	3	4
LARGE_INTESTINE	POLE →	+0.978	+1.056	.005	.002	3	4
STOMACH	CD99 →	-1.781	-1.383	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR90 by Protein deacetylation activity — BONE

Explore this box plot interactively →