Protein deacetylation

Across TCGA cell cohorts, RNA activity of the Protein deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNA, CAV1, and SERPINB7, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein deacetylation activity versus FLNA in BLOOD_Lymphoma (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FLNA →	+2.803	+1.930	<.001	<.001	3	9
BREAST	CAV1 →	+4.192	+0.603	<.001	.005	3	9
BREAST	SERPINB7 →	+1.802	+0.586	<.001	.004	3	8
LIVER	AXL →	+5.475	+0.375	<.001	<.001	3	7
OESOPHAGUS	IGFBP6 →	+3.282	+0.982	<.001	.008	3	6
BLOOD_Lymphoma	TRIO →	+1.890	+1.146	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006476 vs FLNA — BLOOD_Lymphoma

Explore this scatter interactively →