Internal protein amino acid acetylation

Across TCGA patient cohorts, RNA activity of the Internal protein amino acid acetylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC3, SMC1A, and ADNP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Internal protein amino acid acetylation activity versus SMC3 in LSCC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC3 →	+0.296	+0.040	.001	.001	3	8
LSCC	SMC1A →	+0.293	+0.038	.001	.003	3	8
HNSC	ADNP →	+0.400	+0.081	<.001	<.001	3	8
COAD	STAG2 →	+0.263	+0.035	<.001	.001	3	7
GBM	BRD3 →	+0.404	+0.055	<.001	<.001	3	7
LSCC	RAD21 →	+0.250	+0.035	.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006475 vs SMC3 — LSCC

Explore this scatter interactively →