Internal protein amino acid acetylation

Across TCGA cell cohorts, RNA activity of the Internal protein amino acid acetylation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGCL, PLOD1, and KCNJ11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMGCL grouped by Internal protein amino acid acetylation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HMGCL →	-0.970	-1.684	.004	<.001	3	4
OVARY	PLOD1 →	-1.248	-0.993	<.001	.008	3	4
BREAST	KCNJ11 →	+1.240	+0.870	.006	<.001	3	3
BREAST	OSMR →	-2.579	-0.736	.001	.005	3	3
BREAST	HSD11B2 →	+1.596	+0.691	<.001	.001	3	3
LUNG_NSCLC_LUAD	SMIM3 →	-1.484	-0.933	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMGCL by Internal protein amino acid acetylation activity — BONE

Explore this box plot interactively →