N-terminal protein amino acid acetylation

Across TCGA patient cohorts, RNA activity of the N-terminal protein amino acid acetylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A9, RCOR3, and TMOD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-terminal protein amino acid acetylation activity versus S100A9 in HNSC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	S100A9 →	-0.886	-0.082	<.001	<.001	3	5
HNSC	RCOR3 →	+0.309	+0.072	.008	.001	3	5
GBM	TMOD3 →	-0.284	-0.041	.004	.003	3	5
HNSC	EPM2AIP1 →	+0.336	+0.083	<.001	.001	3	5
LSCC	STOM →	-0.316	-0.033	.001	<.001	3	5
LSCC	HMGB3 →	+0.766	+0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006474 vs S100A9 — HNSC

Explore this scatter interactively →