N-terminal protein amino acid acetylation

Across TCGA patient cohorts, RNA activity of the N-terminal protein amino acid acetylation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD93, ABCA9, and PLPP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, N-terminal protein amino acid acetylation activity versus CD93 in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD93 →	-0.616	-0.152	<.001	.004	3	5
PDAC	ABCA9 →	-0.559	-0.425	<.001	.003	3	5
LSCC	PLPP1 →	-0.474	-0.506	.002	.001	3	5
LSCC	ITGA8 →	-0.503	-0.374	.003	.001	3	5
PDAC	LAMA2 →	-0.479	-0.422	.001	.003	3	5
LSCC	FGD1 →	+0.489	+0.323	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006474 vs CD93 — GBM

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