Protein acetylation

Across TCGA patient cohorts, RNA activity of the Protein acetylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC3, WDR5, and HCFC1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acetylation activity versus SMC3 in LSCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC3 →	+0.272	+0.039	<.001	<.001	3	7
GBM	WDR5 →	+0.225	+0.024	.002	.009	3	7
HNSC	HCFC1 →	+0.199	+0.057	<.001	<.001	3	7
UCEC	ZMYM3 →	+0.347	+0.063	<.001	.001	3	7
HNSC	WRNIP1 →	+0.237	+0.053	<.001	<.001	3	7
LSCC	SF3B3 →	+0.203	+0.042	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006473 vs SMC3 — LSCC

Explore this scatter interactively →