Protein acetylation

Across TCGA patient cohorts, RNA activity of the Protein acetylation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, CFD, and DCN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein acetylation activity versus ACTA2 in OV (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACTA2 →	-1.481	-0.299	<.001	.001	3	4
OV	CFD →	-1.071	-0.247	.002	.007	3	4
BRCA	DCN →	-1.573	-0.846	.001	.002	3	4
OV	SMOC2 →	-0.886	-0.215	<.001	.001	3	3
OV	CNRIP1 →	-0.877	-0.320	<.001	<.001	3	3
OV	GALNT15 →	-1.141	-0.284	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006473 vs ACTA2 — OV

Explore this scatter interactively →