Protein dephosphorylation

Across TCGA patient cohorts, RNA activity of the Protein dephosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S102, PRKG1, and RRP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein dephosphorylation activity versus TNS2_S102 in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNS2_S102 →	+0.781	+0.033	.003	.004	3	9
BRCA	PRKG1 →	+0.528	+0.027	.001	<.001	3	9
BRCA	RRP1 →	-0.441	-0.024	.005	.001	3	8
GBM	SEPTIN4 →	+0.532	+0.035	<.001	<.001	3	8
BRCA	SGCD →	+0.487	+0.024	<.001	<.001	3	8
BRCA	STAB1 →	+0.394	+0.028	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006470 vs TNS2_S102 — OV

Explore this scatter interactively →