Protein dephosphorylation

Across TCGA cell cohorts, RNA activity of the Protein dephosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRPC1, SENP3, and ASF1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRPC1 grouped by Protein dephosphorylation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRPC1 →	+0.214	+1.258	<.001	<.001	3	3
SKIN	SENP3 →	+0.226	+1.379	.006	.001	3	3
UPPER_AERODIGESTIVE_TRACT	ASF1A →	+0.098	+1.347	.009	.008	3	3
STOMACH	GLB1 →	-0.317	-2.093	<.001	<.001	3	3
LARGE_INTESTINE	ARF6 →	-0.145	-1.095	.004	.007	2	4
PANCREAS	EMILIN2 →	-0.238	-1.432	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRPC1 by Protein dephosphorylation activity — SKIN

Explore this box plot interactively →