'de novo' protein folding

Across TCGA patient cohorts, RNA activity of the 'de novo' protein folding pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC2, RBM25, and SPDYE1, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 'de novo' protein folding activity versus DNAJC2 in UVM (Pearson r = 0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	DNAJC2 →	+1.448	+0.047	<.001	<.001	3	26
UVM	RBM25 →	+1.756	+0.048	<.001	<.001	3	26
SCLC	SPDYE1 →	+0.658	+0.069	<.001	.001	3	26
UVM	TYW5 →	+1.011	+0.044	<.001	<.001	3	26
UVM	SNORD63B →	+2.270	+0.044	<.001	<.001	3	26
KIRC	CFLAR-AS1 →	+0.584	+0.038	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006458 vs DNAJC2 — UVM

Explore this scatter interactively →