Protein folding

Across TCGA patient cohorts, RNA activity of the Protein folding pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01637, TAS2R8, and TMPRSS4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein folding activity versus LINC01637 in COAD (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC01637 →	-0.548	-0.087	<.001	.004	3	2
COAD	TAS2R8 →	+0.115	+0.165	<.001	<.001	3	1
COAD	TMPRSS4 →	-0.544	-0.120	.003	<.001	3	1
COAD	FAM13A →	-0.936	-0.119	<.001	<.001	3	1
COAD	TEX30 →	-0.547	-0.088	.004	.003	3	1
COAD	KRT27 →	+0.081	+0.084	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006457 vs LINC01637 — COAD

Explore this scatter interactively →