Protein folding

Across TCGA cell cohorts, RNA activity of the Protein folding pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOCS2, COTL1, and MICAL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MOCS2 grouped by Protein folding-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MOCS2 →	+0.674	+0.098	.001	.005	3	6
LUNG_NSCLC_LUSC	COTL1 →	+3.313	+0.198	<.001	.002	3	6
LUNG_NSCLC_LUSC	MICAL2 →	+4.001	+0.198	<.001	.002	3	5
CNS	NUDCD3 →	+0.861	+0.165	.001	.005	3	5
CNS	ZYX →	+1.206	+0.133	<.001	<.001	3	4
LUNG_NSCLC_LUAD	RPS7 →	-0.772	-0.142	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MOCS2 by Protein folding activity — CNS

Explore this box plot interactively →