Protein folding

Across TCGA cell cohorts, RNA activity of the Protein folding pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANP32E, DHX15, and PNO1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein folding activity versus ANP32E in PANCREAS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ANP32E →	+0.926	+0.160	.005	.007	3	6
BLOOD_Myeloma	DHX15 →	-0.625	-0.182	<.001	<.001	3	5
PANCREAS	PNO1 →	+0.809	+0.183	<.001	<.001	3	5
PANCREAS	RPA1 →	+0.938	+0.209	<.001	.002	3	5
LIVER	PCBP1 →	+0.585	+0.296	.004	.002	3	5
BREAST	AURKB →	+0.984	+0.155	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006457 vs ANP32E — PANCREAS

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