Regulation of translational fidelity

Across TCGA patient cohorts, RNA activity of the Regulation of translational fidelity pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL17, METTL3, and ACIN1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational fidelity activity versus METTL17 in ACC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	METTL17 →	+0.889	+0.032	<.001	<.001	3	33
ACC	METTL3 →	+1.184	+0.042	<.001	<.001	3	33
SCLC	ACIN1 →	+1.066	+0.128	.009	<.001	2	33
UVM	DDX55 →	+1.091	+0.026	<.001	<.001	3	32
SCLC	MDN1 →	+1.064	+0.112	<.001	<.001	3	32
DLBC	CEP83 →	+1.062	+0.058	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006450 vs METTL17 — ACC

Explore this scatter interactively →