Regulation of translational fidelity

Across TCGA patient cohorts, RNA activity of the Regulation of translational fidelity pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HABP2, DDR2, and ANTXR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational fidelity activity versus HABP2 in LUAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HABP2 →	-1.161	-0.088	<.001	.008	3	5
BRCA	DDR2 →	-0.518	-0.067	.004	.009	3	5
BRCA	ANTXR2 →	-0.496	-0.101	.001	<.001	3	5
BRCA	DCN →	-1.134	-0.125	<.001	<.001	3	5
BRCA	CDH11 →	-0.834	-0.074	<.001	.003	3	5
BRCA	COL8A1 →	-1.227	-0.114	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006450 vs HABP2 — LUAD

Explore this scatter interactively →