Regulation of translational fidelity

Across TCGA cell cohorts, RNA activity of the Regulation of translational fidelity pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTN4IP1, KLHL23, and LRPPRC, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational fidelity activity versus RTN4IP1 in OVARY (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RTN4IP1 →	+0.924	+0.254	.005	.001	3	7
STOMACH	KLHL23 →	+1.436	+0.137	<.001	.009	3	6
SKIN	LRPPRC →	+0.472	+0.177	.005	.005	3	6
OVARY	SDHAF3 →	+1.055	+0.209	<.001	<.001	3	5
BLOOD_Myeloma	FAM50A →	-1.331	-0.269	.001	.004	3	5
URINARY_TRACT	GMCL1 →	+0.754	+0.280	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006450 vs RTN4IP1 — OVARY

Explore this scatter interactively →