Regulation of translational elongation

Across TCGA cell cohorts, RNA activity of the Regulation of translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QBP, MRM3, and SCO1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational elongation activity versus C1QBP in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C1QBP →	+1.232	+0.414	.002	.003	2	12
OVARY	MRM3 →	+1.150	+0.402	.002	.001	3	8
KIDNEY	SCO1 →	+0.789	+0.229	.007	.002	2	9
OVARY	HNRNPA1 →	+0.616	+0.236	.002	.005	3	8
LUNG_SCLC	CD9 →	-2.767	-0.154	.008	.003	3	7
OVARY	EIF5A →	+1.163	+0.420	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006448 vs C1QBP — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →