Regulation of translational initiation

Across TCGA patient cohorts, RNA activity of the Regulation of translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBXN7, CACNA2D1, and BRD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational initiation activity versus UBXN7 in LSCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBXN7 →	+0.427	+0.041	<.001	<.001	3	5
CCRCC	CACNA2D1 →	+0.570	+0.029	<.001	<.001	3	5
GBM	BRD3 →	+0.257	+0.025	.002	.005	3	5
HNSC	BICDL2_S36 →	-0.765	-0.124	.001	.002	3	5
HNSC	DHX32 →	-0.323	-0.087	<.001	.006	3	5
CCRCC	MAP1A_S667 →	+0.502	+0.024	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006446 vs UBXN7 — LSCC

Explore this scatter interactively →