Regulation of translational initiation

Across TCGA cell cohorts, RNA activity of the Regulation of translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1G, HSP90AB1, and MTHFD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of translational initiation activity versus EEF1G in CNS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EEF1G →	+0.681	+0.158	.002	<.001	3	6
PANCREAS	HSP90AB1 →	+1.208	+0.427	.001	<.001	3	6
PANCREAS	MTHFD1 →	+1.171	+0.363	<.001	<.001	3	6
LIVER	EIF4H →	+0.527	+0.231	<.001	.001	3	6
PANCREAS	KRI1 →	+0.807	+0.213	.004	.005	2	7
PANCREAS	DNMT1 →	+1.345	+0.447	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006446 vs EEF1G — CNS

Explore this scatter interactively →