Translational termination

Across TCGA patient cohorts, RNA activity of the Translational termination pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM177A1P1, C9orf153, and LIPJ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational termination activity versus FAM177A1P1 in BRCA (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM177A1P1 →	+0.301	+0.125	<.001	.004	3	4
OV	C9orf153 →	+0.125	+0.177	.001	.003	3	3
OV	LIPJ →	-0.173	-0.120	.007	.004	3	3
PDAC	ZFP64 →	+0.160	+0.118	.001	<.001	3	3
PDAC	ASS1P7 →	+0.113	+0.115	.008	.008	3	3
LUAD	EIF2S3 →	+0.356	+0.168	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006415 vs FAM177A1P1 — BRCA

Explore this scatter interactively →