Translational termination

Across TCGA cell cohorts, RNA activity of the Translational termination pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA3, GNL3, and MAK16, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational termination activity versus LAMA3 in SKIN (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LAMA3 →	-1.477	-0.232	.007	<.001	3	7
SKIN	GNL3 →	+0.759	+0.266	.004	<.001	3	6
OVARY	MAK16 →	+0.935	+0.473	<.001	.008	3	6
OVARY	ABCE1 →	+0.861	+0.430	<.001	<.001	3	6
OVARY	RPL4 →	+0.651	+0.518	<.001	.003	3	6
LUNG_SCLC	CHCHD4 →	+0.855	+0.344	<.001	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006415 vs LAMA3 — SKIN

Explore this scatter interactively →