Translational elongation

Across TCGA patient cohorts, RNA activity of the Translational elongation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL6, RPL3, and RPS6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational elongation activity versus RPL6 in LUAD (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL6 →	-0.260	-0.028	.003	<.001	3	8
LUAD	RPL3 →	-0.403	-0.039	<.001	<.001	3	7
LUAD	RPS6 →	-0.296	-0.035	.002	<.001	3	7
BRCA	RPL5 →	-0.296	-0.041	<.001	<.001	3	7
BRCA	SORBS1 →	+0.539	+0.033	<.001	<.001	3	7
GBM	RPL7 →	-0.411	-0.048	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006414 vs RPL6 — LUAD

Explore this scatter interactively →