Translational elongation

Across TCGA patient cohorts, RNA activity of the Translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPP5A, SEC24A, and NES, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational elongation activity versus INPP5A in GBM (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	INPP5A →	-0.511	-0.166	.001	.001	3	4
BRCA	SEC24A →	+0.715	+0.140	<.001	<.001	3	4
BRCA	NES →	-0.689	-0.116	.007	.007	3	4
OV	LYRM1 →	+0.539	+0.165	.005	.007	3	4
UCEC	PI4KAP2 →	-0.386	-0.170	.003	.005	3	4
CCRCC	ADGRL3 →	-0.635	-0.103	.009	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006414 vs INPP5A — GBM

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