Translational elongation

Across TCGA cell cohorts, RNA activity of the Translational elongation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGPAT5, CHMP4B, and SARS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational elongation activity versus AGPAT5 in LUNG_NSCLC_LUSC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AGPAT5 →	+0.629	+0.173	<.001	.007	3	4
CNS	CHMP4B →	-0.514	-0.120	.001	<.001	3	4
BLOOD_Leukemia	SARS1 →	+1.045	+0.130	.002	.006	2	5
LUNG_SCLC	DHX38 →	+0.654	+0.128	.001	.002	3	4
LUNG_SCLC	POLR3E →	+0.749	+0.099	.007	.008	3	4
SKIN	ROCK2 →	-1.431	-0.141	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006414 vs AGPAT5 — LUNG_NSCLC_LUSC

Explore this scatter interactively →