Translational initiation

Across TCGA patient cohorts, RNA activity of the Translational initiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEK, RFX3-AS1, and ARHGAP6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational initiation activity versus TEK in BRCA (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TEK →	-1.028	-0.242	.007	.003	3	3
BRCA	RFX3-AS1 →	-0.982	-0.183	.002	.006	3	3
COAD	ARHGAP6 →	-0.735	-0.154	<.001	.001	3	3
COAD	TOR1AIP1 →	-0.343	-0.116	.006	.007	3	3
OV	RHOJ →	-0.779	-0.234	.003	.001	3	3
OV	NPTN →	-0.559	-0.183	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006413 vs TEK — BRCA

Explore this scatter interactively →