Translational initiation

Across TCGA patient cohorts, RNA activity of the Translational initiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL11, RPL22, and RPL23, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Translational initiation activity versus RPL11 in OV (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL11 →	+0.337	+0.263	<.001	<.001	2	3
BRCA	RPL22 →	+0.594	+0.287	.003	<.001	3	2
COAD	RPL23 →	+0.472	+0.163	.001	.001	3	2
BRCA	RPS3 →	+0.388	+0.266	<.001	<.001	3	2
COAD	RPS3A →	+0.223	+0.144	<.001	<.001	3	2
BRCA	SCRIB_S1486 →	+0.980	+0.331	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006413 vs RPL11 — OV

Explore this scatter interactively →