mRNA export from nucleus

Across TCGA patient cohorts, RNA activity of the mRNA export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD3, RCC2, and SMARCD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA export from nucleus activity versus BRD3 in GBM (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BRD3 →	+0.297	+0.036	.007	.006	3	7
LSCC	RCC2 →	+0.381	+0.045	<.001	<.001	3	7
LSCC	SMARCD1 →	+0.261	+0.046	<.001	<.001	3	6
HNSC	SMC3 →	+0.296	+0.099	<.001	<.001	3	6
HNSC	ZNF638 →	+0.330	+0.102	<.001	<.001	3	6
LSCC	CDC5L →	+0.297	+0.062	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006406 vs BRD3 — GBM

Explore this scatter interactively →