mRNA export from nucleus

Across TCGA cell cohorts, RNA activity of the mRNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNIH3, RIPK2, and B9D2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNIH3 grouped by mRNA export from nucleus-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CNIH3 →	+1.396	+0.217	.003	.006	3	5
BONE	RIPK2 →	-1.132	-0.161	.002	.002	3	4
KIDNEY	B9D2 →	+0.897	+0.192	.006	.002	3	4
KIDNEY	NOB1 →	-1.157	-0.258	<.001	.002	3	4
CNS	AMPD3 →	+0.985	+0.127	<.001	.001	3	4
BONE	MED30 →	-0.718	-0.105	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNIH3 by mRNA export from nucleus activity — OESOPHAGUS

Explore this box plot interactively →