mRNA export from nucleus

Across TCGA cell cohorts, RNA activity of the mRNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCAF4, FAM161A, and CIB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA export from nucleus activity versus SCAF4 in LUNG_SCLC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SCAF4 →	+0.533	+0.199	.005	<.001	3	6
SOFT_TISSUE	FAM161A →	+1.420	+0.196	.001	<.001	3	6
LUNG_SCLC	CIB1 →	-1.436	-0.283	.001	.001	3	6
SOFT_TISSUE	GTF3C4 →	+0.816	+0.174	.006	.003	2	7
BREAST	NASP →	+1.119	+0.274	<.001	<.001	3	6
STOMACH	SUCLG2 →	-1.254	-0.268	.007	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006406 vs SCAF4 — LUNG_SCLC

Explore this scatter interactively →