RNA export from nucleus

Across TCGA patient cohorts, RNA activity of the RNA export from nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B3, LAS1L, and ADNP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA export from nucleus activity versus SF3B3 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SF3B3 →	+0.192	+0.084	<.001	.009	3	6
LSCC	LAS1L →	+0.227	+0.042	<.001	<.001	3	6
HNSC	ADNP →	+0.444	+0.108	<.001	<.001	3	6
LSCC	DHX9 →	+0.188	+0.045	<.001	<.001	3	6
LSCC	GTF3C5 →	+0.358	+0.050	<.001	<.001	3	6
LSCC	RAE1 →	+0.164	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006405 vs SF3B3 — HNSC

Explore this scatter interactively →