tRNA modification

Across TCGA patient cohorts, RNA activity of the tRNA modification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR5, DHX9, and SND1_S645, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA modification activity versus WDR5 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR5 →	+0.269	+0.041	<.001	<.001	3	6
LSCC	DHX9 →	+0.225	+0.035	<.001	<.001	3	6
HNSC	SND1_S645 →	-0.616	-0.063	<.001	.003	3	6
LSCC	BRD8 →	+0.251	+0.031	<.001	.001	3	6
GBM	FKBP15_S1012 →	-0.408	-0.024	<.001	<.001	3	6
LUAD	ZMYM4_S122 →	+0.240	+0.023	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006400 vs WDR5 — LSCC

Explore this scatter interactively →