tRNA modification

Across TCGA cell cohorts, RNA activity of the tRNA modification pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCSTN, CALM2, and CBWD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NCSTN grouped by tRNA modification-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NCSTN →	-0.509	-0.268	.004	.002	3	4
BREAST	CALM2 →	+0.640	+0.224	.001	.001	3	4
SOFT_TISSUE	CBWD3 →	+0.999	+0.214	.003	.003	3	4
BLOOD_Leukemia	CEP85 →	+0.525	+0.237	.002	.007	2	4
BLOOD_Leukemia	C20orf194 →	-0.921	-0.348	.003	.006	3	3
LIVER	ZNF497 →	-0.532	-0.303	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NCSTN by tRNA modification activity — LIVER

Explore this box plot interactively →