tRNA metabolic process

Across TCGA patient cohorts, RNA activity of the tRNA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SND1_S645, BRD8, and CD2AP_S510, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA metabolic process activity versus SND1_S645 in GBM (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SND1_S645 →	-1.067	-0.035	.001	.001	3	7
LSCC	BRD8 →	+0.350	+0.037	<.001	<.001	3	6
GBM	CD2AP_S510 →	-0.550	-0.032	<.001	<.001	3	6
GBM	FKBP15_S1012 →	-0.492	-0.045	<.001	<.001	3	6
LSCC	GATAD2B →	+0.358	+0.043	<.001	<.001	3	6
LSCC	HDAC2 →	+0.427	+0.045	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006399 vs SND1_S645 — GBM

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