tRNA metabolic process

Across TCGA cell cohorts, RNA activity of the tRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB12, PBX2, and EHMT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB12 grouped by tRNA metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZBTB12 →	-0.731	-0.144	<.001	<.001	3	5
LUNG_SCLC	PBX2 →	-0.945	-0.121	.004	.007	3	4
CNS	EHMT2 →	-0.587	-0.158	<.001	<.001	3	4
BREAST	ZCCHC3 →	-0.644	-0.118	.002	.003	3	4
STOMACH	SYTL2 →	+2.457	+0.162	.008	.007	3	4
CNS	MED13 →	-0.336	-0.095	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB12 by tRNA metabolic process activity — CNS

Explore this box plot interactively →