tRNA metabolic process

Across TCGA cell cohorts, RNA activity of the tRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF138, AIMP2, and HNRNPA1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA metabolic process activity versus RNF138 in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNF138 →	+1.055	+0.162	.002	<.001	3	8
LIVER	AIMP2 →	+1.034	+0.283	.004	<.001	3	7
BREAST	HNRNPA1 →	+0.712	+0.133	<.001	.001	3	7
PANCREAS	NPM1 →	+1.345	+0.224	.001	<.001	3	7
BREAST	NPM3 →	+1.311	+0.157	.001	<.001	3	7
PANCREAS	RPL3 →	+0.746	+0.210	.003	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006399 vs RNF138 — LARGE_INTESTINE

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