mRNA 3'-end processing by stem-loop binding and cleavage

Across TCGA patient cohorts, RNA activity of the mRNA 3'-end processing by stem-loop binding and cleavage pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBE2M, NOSIP, and DBN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA 3'-end processing by stem-loop binding and cleavage activity versus UBE2M in PDAC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	UBE2M →	+0.206	+0.045	.002	<.001	3	6
BRCA	NOSIP →	+0.311	+0.031	<.001	<.001	3	6
CCRCC	DBN1 →	+0.382	+0.034	.001	<.001	2	7
BRCA	IRF2BP1 →	+0.468	+0.052	<.001	<.001	3	6
CCRCC	KXD1 →	-0.222	-0.032	.003	.003	3	6
UCEC	LIG1 →	+0.471	+0.067	.001	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006398 vs UBE2M — PDAC

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