mRNA 3'-end processing by stem-loop binding and cleavage

Across TCGA cell cohorts, RNA activity of the mRNA 3'-end processing by stem-loop binding and cleavage pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEXA, YEATS2, and STRBP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA 3'-end processing by stem-loop binding and cleavage activity versus HEXA in BLOOD_Leukemia (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HEXA →	-0.725	-0.315	<.001	.009	3	5
LUNG_SCLC	YEATS2 →	+0.895	+0.236	.005	.001	3	4
PANCREAS	STRBP →	+0.735	+0.229	.001	.001	3	4
PANCREAS	CTSA →	-1.410	-0.242	.001	.003	3	4
STOMACH	OSGIN1 →	-1.697	-0.201	.001	.001	3	4
BLOOD_Leukemia	RBMX →	+0.461	+0.315	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006398 vs HEXA — BLOOD_Leukemia

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