Mitochondrial transcription

Across TCGA patient cohorts, RNA activity of the Mitochondrial transcription pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX37, LINC01480, and TMPO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial transcription activity versus DHX37 in LUAD (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DHX37 →	+0.368	+0.288	.001	.006	3	3
COAD	LINC01480 →	-0.576	-0.370	.004	.003	3	3
UCEC	TMPO →	+0.666	+0.430	<.001	.003	3	3
UCEC	SHMT2 →	+0.831	+0.531	<.001	.002	3	3
UCEC	EMSLR →	+0.302	+0.449	.002	.001	3	3
UCEC	MARS2 →	+0.483	+0.428	.008	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006390 vs DHX37 — LUAD

Explore this scatter interactively →